QT Prolongation: Use REMERON/REMERONSolTab with caution in patients with risk factors for QT prolongation
This trial showed a positive relationship between mirtazapine concentrations and prolongation of the QTc interval
The focus of
A prolonged QTc often arouses concern in clinical practice, as it can be followed, in rare cases, by the life-threatening polymorphic ventricular tachyarrhythmia
Antidepressive Agents / adverse effects* Long QT Syndrome /
The effect of REMERON (mirtazapine) on QTc interval was assessed in a clinical randomized trial with placebo and positive (moxifloxacin) controls involving 54
We investigated the effects of atypical
3, 7) Angle-Closure Glaucoma: Angle closure glaucoma has occurred in patients with untreated
Recommended Dosage
Those with prolonged QT are at risk for one of the potentially deadly arrhythmias known as torsades de pointes
Selecting an alternative antidepressant to citalopram or agents that may be considered “higher risk” can be
presence of congenital QT prolongation)
It increases the amount of serotonin and norepinephrine in the brain, hormones that help regulate mood
Other antidepressant options, namely bupropion or mirtazapine may be considered since they carry minimal to no risk of QT prolongation
6 msec for mirtazapine and –3
ECG machines are often inaccurate; confirm with manual measure
In rare cases, QT prolongation can cause: Taking these medications with mirtazapine may increase your risk of a heart rhythm problem called QT prolongation
Manic episodes: greatly increased energy
4) QT Prolongation: Use REMERON/REMERONSolTab with caution in patients with risk factors for QT
6 Drug Reaction with Eosinophilia and Systemic Symptoms Antidepressant (DRESS) 2
QT prolongation can remain asymptomatic or lead to torsades de pointes (TdP), a rare tachyarrhythmia which can be life-threatening or nearly fatal due to ventricular fibrillation and sudden cardiac death
11 DESCRIPTION
rate, BP, serotonin syndrome sx, especially during initiation/titration; decr
1 A normal QT interval is less than 450 ms in men and 460 ms in women